Basic immunology abbas pdf 5th edition full for free
As the body s first line of defence, the innate immune system comprises physical barriers and some ular defences. The immune response can be broadly categorised into two systems: innate immunity and acquired immunity.
The aim of this first tutorial is to provide an overview of the immune response whilst the second tutorial will concentrate on immunology in clinical practice. It is important to have an understanding of the fundamental science behind immunology, so we can reduce the risk to our patients and understand why some patients may be particularly prone to infections. As anaesthetists we challenge the immune system through our everyday practice, whether this is during the placement of intravascular devices, tracheal intubation or the administration of drugs. INTRODUCTION Immunity describes the ability to fight infection and is dependent on a highly functional immune system. This binds to antigen on pathogens and labels the for destruction by complement or phagocytic s. T-s can be CD8 or CD4, the former are known as cytotoxic T-s and the latter become T-helper s. The acquired immune system is a specific response to a certain pathogen and is principally brought about by T-s, B-s, immunoglobulin and complement. IgG is responsible for mast degranulation Key Points The innate immune response is nonspecific and destroys pathogens mainly through phagocytosis and activation of complement. Specificity for antigen depends on the light chains e. Consists of one heavy chain and two light chains d.
Is present in the IgA isoform on mucous membranes c. Produce more than one clone of antibody 3. They display receptors of similar morphology to the immunoglobulin produced by that c. They are so named as they mature in the bone marrow b. Causes large amounts of histamine release 2. Involves activation of lymphocytes in the periphery c. Can be responsible for autoimmune diseases b. The answers can be found at the end of the article, together with an explanation. Tushar Dixit Consultant Anaesthetist, St Helens and Knowsley NHS Trust, UK Edited by Dr Emma Giles Correspondence to 22 nd DEC 2015 QUESTIONS Before continuing, try to answer the following questions. Katharine Kennedy Anaesthetics Registrar, Mersey Deanery, UK Dr. 1 B A S I C S C I E N C E Tutorial 323 IMMUNOLOGY FOR ANAESTHETISTS Part 1 Basic Immunology Dr.